Identification and modulation of Regulatory T cell (Treg) specific receptor, to manipulate Treg function for treatment of autoimmune diseases, cancer and infectious diseases.
Enhancement of Treg function could suppress autoimmune diseases, while inhibition or elimination of Treg cells could enhance immunotherapy of cancer and infectious diseases, as well as aid bone marrow engraftment. Hence, therapeutic manipulation of Treg in vivo requires identification of Treg-specific receptors. This invention identifying LAG-3 as an exclusive Treg cell receptor regulating Treg function can be employed for:
• Developing new agonists and antagonists against LAG3 for the recognition, inhibition and activation of Treg cells
• Screening drugs and developing novel therapeutics for autoimmune diseases, cancer and infectious diseases
• Enhancing bone marrow transplantation
Johns Hopkins researchers have identified LAG-3 as a Treg specific marker modulating its suppressor activity. CD4+Tcells (Treg precursors) having high LAG-3 expresssion, display in vitro suppressor activity; and antibodies to LAG-3 inhibit the suppression both in vitro and in vivo. Hence, agonists and antagonists against LAG-3 can be employed to activate or inhibit Treg cells respectively. Manipulation of Treg cells in this manner can therefore be used to enhance immunotherapy of autoimmune diseases, cancer and infectious diseases, as well as enhance lymphocyte engraftment in settings of donor lymphocyte infusion, bone marrow transplantation and adoptive T cell transfer.
Looking for Partners
To develop & commercialize the technology for the testing of drugs and treatment of autoimmune diseases, cancer, chronic infection and enhancement of lymphocyte engraftment after bone marrow engraftment.
Stage of Development
Animal data and in vitro data in murine T cells.
Drew M. Pardoll, Charles Drake, Ching-Tai Huang, Jonathan Powell, Dario Vignali, Creg Jason Workman
Issued U.S. Patent No. 8,551,481; U.S. Published Patent Application No. 2013-0095114 A1
J Immunol. 2005 Jan 15;174(2):688-95.
Regulatory T cells, autoimmune disease, cancer, bone marrow transplantation, LAG-3